Most critics agree with varying emphasis that this is one of the most significant lines in the Watchman's speech, because of its emphasis on Clytaemnestra's unique masculinity. But the same interpreters widely disagree in deciding what exactly was her most masculine trait. In other words the meaning of the –βουλον part of the compound is in dispute. Here are some English renderings: ‘whose will is as a man's’ ; ‘manly’ ; ‘with man's resolve’ ; ‘into the council of men’ ; (...) ‘man-passionéd’ ; ‘man's mind’ and ‘man-like spirit’ ; ‘manly-counselling’ ; ‘shrewd-purposed as a man's’. Thus, as my italics show, we have will, resolve, passion, mind, spirit, counsel, and purpose, a pretty array of would-be synonyms, for the Greek βουλον, an area whose semantic termini are βουλεύομαɩ = I wish and βουλεύομαɩ = I deliberate, plan. The purpose of this article is to show that every ounce of interpretative weight must be put into insistence on the second meaning, and that unless this be done appreciation of two important motifs in the play will be impaired. The scholiast saw that βουλεύομαɩ was the operative element in ⋯νδρόβουλον, and wrote τò μείζονα ἣ κατ⋯ γυναȋκα βουλευόμενον ἣ κατ⋯ ⋯νδρòς βουλευομένης.1 His second alternative is otiose but scarcely culpable in the light of Aeschylus' amazing exploitation of verbal ambiguity throughout this play.2. (shrink)

Soren Kierkegaard and William Faulkner are, to my mind, the most seminal religious thinker and the most brilliant novelist of our time. For a good many years I admired their works from a distance. Then in 1966 or so, my good friend and teacher William H. Poteat of Duke University suggested that I get to know them better by doing an essay on them. This book is the result, though I by no means want to hold Professor Poteat (...) responsible for anything but merit of this venture, if, indeed, it has any. (shrink)

Cell cycle dynamics has emerged as a key regulator of stem cell fate decisions. In particular, differentiation decisions are associated with the G1 phase, and recent evidence suggests that self‐renewal is actively regulated outside of G1. The mechanisms underlying these phenomena are largely unknown, but direct control of gene regulatory programs by the cell cycle machinery is heavily implicated. A recent study sheds important mechanistic insight by demonstrating that in human embryonic stem cells (hESCs) the Cyclin‐dependent kinase CDK2 controls a (...) wide‐spread epigenetic program that drives transcription at differentiation‐related gene promoters specifically in G1. Here, we discuss this finding and explore whether similar mechanisms are likely to function in multipotent stem cells. The implications of this discovery toward our understanding of stem cell‐related disease are discussed, and we postulate novel mechanisms that position the cell cycle as a regulator of cell fate gene networks at epigenetic, transcriptional and post‐transcriptional levels. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Having lived in Rita Caccamo's Rome and other Italian cities for long periods, I was intrigued by Arthur J. Vidich's foreword, which notes the sociologist Caccamo's Roman background and hence her ability to see Middletown as an anthropologist might, from “the perspective of an ‘other’”—a position, he explains, very different from that of Robert S. and Helen M. Lynd, who made Muncie, Indiana, famous in their 1929 and 1937 studies. There are hints of that perspective in these pages. In the (...) preface to this edition, Caccamo remarks on the sense of alienation she felt while living in Muncie as she worked in the archives; and in a very brief concluding chapter, “The Nineties in Middletown,” she suggests that Muncie suffers, like the rest of the country, from “the lack of cumulative experience” of the sort that Rome has plenty of. But that's about it for anthropology and the “other,” at least on the surface. “We European scholars,” she writes, “need to look at these phenomena without our European points of reference” .What stands out in this assessment of Middletown , Middletown in Transition , and Theodore H. Caplow's late‐1970s investigation is Caccamo's deep affinity with the Lynds' radical, pessimistic argument: that Middletown's community life was rapidly being eroded by limited economic mobility and, especially, by a consumer culture that increasingly valued money and the things it would buy above all else—and that Munsonians, in the grip of a power elite and overwhelmed by mass culture, were helpless to do anything about it. Although Caccamo sees weaknesses in the Lynds' schema—a simplistic two‐class model, a lack of attention to immigrants and outsiders, the failure to appreciate the adventurousness that comes with modernity, little recognition of the potential of Muncie's residents to challenge and resist power—none of these arguments is pursued with much conviction. Instead, she presents the Lynds as part of a larger group of interwar sociologists who understood the American experience very well. By the same token, she takes Caplow's “Middletown III” to task for its unwarranted optimism about family life, religion, class, and other matters. In a final assessment, she underscores Muncie's obsessions with privacy and marriage and disregard for single people. Caccamo believes that late twentieth‐century Muncie manifests the same maladies that the Lynds uncovered some seventy years ago.Those familiar with the literature on Middletown will not, I suspect, find much that is new here, except perhaps for an extensive discussion of the Lynds' controversial dependence on, and use of, the work of Lynn Perrigo for their chapter “The X Family” in the 1937 volume. What they will find is part biography, part history of sociology, part polemic: an effort to understand the Lynds as “committed intellectuals” and to appreciate what it was they found so repugnant about life in a city they had decided was typical of the American experience. That Caccamo succeeds so well has much to do with what some may see as an uncritical acceptance of Marxist theory and Frankfurt school arguments about the mass media that underpinned or reinforced the Lynds' work, but much to do also with the outsider Caccamo's Rome, whose coffee bars, neighborhoods, and vibrant streets bear witness to what Muncie once was, and could have been. (shrink)

Louis Agassiz.--Address at the Emerson Centenary in Concord.--Robert Gould Shaw.--Francis Boott.--Thomas Davidson: a knight-errant of the intellectual life.--Herbert Spencer's autobiography.--Frederick Myers' services to psychology.--Final impressions of a psychical researcher.--On some mental effects of the earthquake.--The energies of men.--The moral equivalent of war.--Remarks at the peace banquet.--The social value of the college-bred.--The university and the individual: The Ph.D. octopus. The true Harvard. Stanford's ideal destiny.--A pluralistic mystic.

‘Bayesian epistemology’ became an epistemological movement in the 20th century, though its two main features can be traced back to the eponymous Reverend Thomas Bayes (c. 1701-61). Those two features are: (1) the introduction of a formal apparatus for inductive logic; (2) the introduction of a pragmatic self-defeat test (as illustrated by Dutch Book Arguments) for epistemic rationality as a way of extending the justification of the laws of deductive logic to include a justification for the laws of inductive logic. (...) The formal apparatus itself has two main elements: the use of the laws of probability as coherence constraints on rational degrees of belief (or degrees of confidence) and the introduction of a rule of probabilistic inference, a rule or principle of conditionalization. (shrink)

The idea of representation has been central in discussions of intentionality for many years. But only more recently has it begun playing a wider role in the philosophy of mind, particularly in theories of consciousness. Indeed, there are now multiple representational theories of consciousness, corresponding to different uses of the term "conscious," each attempting to explain the corresponding phenomenon in terms of representation. More cautiously, each theory attempts to explain its target phenomenon in terms of _intentionality_, and assumes that intentionality (...) is representation. (shrink)

Epiphenomenalism is the view that mental events are caused by physical events in the brain, but have no effects upon any physical events. Behavior is caused by muscles that contract upon receiving neural impulses, and neural impulses are generated by input from other neurons or from sense organs. On the epiphenomenalist view, mental events play no causal role in this process. Huxley (1874), who held the view, compared mental events to a steam whistle that contributes nothing to the work of (...) a locomotive. James (1879), who rejected the view, characterized epiphenomenalists' mental events as not affecting the brain activity that produces them "any more than a shadow reacts upon the steps of the traveller whom it accompanies". (shrink)

The British journalist Christopher Hitchens has recently noted that the extraordinary excitement created by l’affaire Pound, an excitement sustained for now some forty years, is partly the result of having no fewer than three debates going on whenever the poet’s legal situation and his consequent hospitalization are discussed. As Hitchens says, those questions are: “First, was Pound guilty of treason? If not, or even if so, was he mad? Third, was he given privileged treatment for either condition?”1 I propose to (...) discuss all three issues in a way that fairly reflects the fact that I am neither a physician nor a lawyer. What I know of the state of medical expertise, both today and in the period of time from 1943 to 1958 , leads me, as a layman, to believe that there is an enormous latitude of understanding among medical professionals as to the precise meaning of “insanity.” At one extreme, for some distinguished physicians, the term means almost nothing. They see it as a legal term and as therefore irrelevant to them; some of them follow the line of reasoning developed by Thomas Szasz over his long writing career, namely that “mental illness” if not illness in any ordinary sense of the term.2 For other medical practitioners, it does mean something, but only when it is redefined into much smaller subcategories and enriched with much more precise terminology, and when the given patient and his full range of circumstances are considered.What I know of the legal understanding of insanity is that there has been and is now little firm agreement about “insanity” or “madness.” Equally competent juries and courts have been able to set down findings that are more or less plausible on their face but do not seem to comport at all with each other. I tentatively conclude that whatever “insanity” now is in the United States, and whatever it was when Pound was found unfit to stand trial in 1945, the standard is not the lucid simplicity of the M’Naghten test, namely, the ability of the accused to understand the difference between “right” and “wrong.” Human mind, self-awareness, and motivations are vastly more complicated than such a test would imply. 1. Christopher Hitchins, “American Notes,” Times Literary Supplement, 21 Oct. 1983, p. 1160.2. See Thomas Szasz, Insanity for a synthesis of his ideas as formulated in some eighteen books. William M. Chace is professor of English and Vice Provost for Academic Planning and Development at Stanford University. He is author of The Political Identities of Ezra Pound and T. S. Eliot , Lionel Trilling: Criticism and Politics , and scholarly essays on writers including Wyndham Lewis, D. H. Lawrence, T. E. Lawrence, and James Joyce. He is now working on a study of the ways in which American culture in this century has been subjected to critical analysis. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:MIMESIS AND EMPATHY IN HUMAN BIOLOGY William B. Hurlbut, M.D. Stanford University Thou shalt not avenge, nor bear any grudge against the children of thy people, but thou shalt love thy neighbor as thyself: I am the Lord. (Leviticus. 19:18) The light of the body is the eye: if therefore thine eye be single, thy whole body shall be full of light. But if thine eye be (...) evil, thy whole body shall be full of darkness. If therefore the light that is in thee be darkness, how great is that darkness! (Matthew. 6:22-23) On the levels both ofcommon discourse and scientific description, the concept of empathy has found renewed popularity. Like a bridge that spans disparate realms, the idea of empathy can reconnect neurophysiology with psychology and social theory, and reestablish the grounds for a natural concept of ethics. Specifically, it can connect mimetic theory with a possible basis in biology, since empathy seems to represent an extension ofmimetic processes across the animal kingdom. For this reason, empathy/mimesis might be the grounds for a concept of ethics based on natural observation. Drawn from a German term Einfühlung, which means "feeling into," empathy carries the concept of "getting into the feelings of someone else" (deWaal 79). As a medium for the formation of meaningful bonds and William Hurlbut15 sensitive associations, the concept of empathy has taken on, in popular discourse, the somewhat sentimental notion ofsympathy. In the scientific description, however, empathy is seen as the highest human expression of a broader biological capacity for mimesis that seems inextricable from the very progress ofthe phylogenetic process. Among the earliest life forms, organisms drew information from one another to pattern and coordinate such basic biological functions as reproduction and nurture. But with the increased complexity of multicellular creatures, new means of communication arose, making possible more flexible adaptation and sociability. Gradually the direct chemical coordination suitable for collectives or swarms gave way to richer and more individual communication between organisms of higher forms of differentiation. The externally evident demarcation ofthe head region, with its organs ofsensory perception and communication, evolved in parallel with internal cerebral structures capable ofprocessing more complex impressions of the surrounding environment and coordinating greater freedom of motion. These vital powers of action and awareness in turn came to be governed, guided and integrated by an inner felt sense of need, goal or purpose. As Leon Kass says, "desire, not DNA, is the deepest principle of life" (Kass 1994, 48). This quality of "inwardness" is paralleled by an equally complex differentiation and integration of the external "look" ofthe animal. This "look," which is the literal translation of the Latin root of our word species, is the result of a genetically determined plan as important as any internal vital organ. It provides the unity of form that reveals or selectively conceals the inner life of the organism. It communicates and coordinates vital information regarding sexual and other social interactions. This upward process ofcomplex integrated organization of the "inner life" and the external action and presentation of selfreaches its fullest expression in the human form. Along with upright posture and its freeing ofthe hands as tools of "gnostic touching," comes a reordering of the senses and a highly flexible, furless canvas of selfpresentation we call the face (Kass 1985, 287). Upwards through mammalian evolution there is a progressive refinement of the structures of the face that facilitate active and increasingly subtle communication and penetration into the life of the other. With more than 30 finely tuned muscles of facial expression and vocal control, human beings are capable of a wide array of communicative 16 Mimesis andEmpathy expressions of emotions and intentions. Paul Ekman claims to have discerned more than 1 8 forms of smiling, each with a distinct meaning (66). With upright posture came a retraction ofthe snout and bilateral stereoscopic vision. Sight replaced smell as the prominent sense. Whereas smell required direct chemical contact, and sound gave formless information, sight gave a knowing and accurate encounter with the form and unity ofwholes. Sight allowed rapid perception ofobjects and actions at distant horizons. The detached beholding of sight allowed a deeper and more accurate apprehension of... (shrink)

David Hume's relatively short essay 'Of the Standard of Taste' deals with some of the most difficult issues in aesthetic theory. Apart from giving a few pregnant remarks, near the end of his discussion, on the role of morality in aesthetic evaluation, Hume tries to reconcile the idea that tastes are subjective (in the sense of not being answerable to the facts) with the idea that some objects of taste are better than others. 'Tastes', in this context, are the pleasures (...) or displeasures that a person can take in the beauties of poems, paintings, and other artistic compositions (though Hume also wants to stress the continuities between tastes, so understood, and the bodily sense of taste). The position at which Hume arrives in the essay (despite some dialectical unclarity) is that some people – the 'true judges'– determine by their 'joint verdict' which works are meritorious. This solution continues to exercise a fascination, as does Hume's complicated route to it. Author Recommends: Paul Guyer, 'The Standard of Taste and the "Most Ardent Desire of Society" ', Values of Beauty (Cambridge: Cambridge University Press, 2005), 37–76. This paper places 'Of the Standard of Taste' in an especially rich context, and asks why Hume concentrates on true judges instead of the improvement of one's own taste. Mary Mothersill, 'Hume: "Of the Standard of Taste" ', Beauty Restored (Oxford: Clarendon Press, 1984), 177–208. This chapter, embedded in an exposition of Mothersill's 'First Thesis' (the denial that there are principles of taste) and 'Second Thesis' (the affirmation that some judgments of taste are genuine judgments), gives a detailed running commentary on Hume's essay. A shorter self-contained version of the chapter appeared as 'Hume and the Paradox of Taste' in Aesthetics: A Critical Anthology , 2nd ed., eds. George Dickie, Richard Sclafani, and Ronald Roblin (New York, NY: St. Martin's Press, 1989, 269–86). Jerrold Levinson, 'Hume's Standard of Taste: The Real Problem', Journal of Aesthetics and Art Criticism (2002): 227–38. An importance recent article, Levinson's piece argues that the 'real' difficulty with Hume's essay has gone unnoticed: why should I care about what Hume's true judges think? Christopher Williams, 'Some Questions in Hume's Aesthetics', Philosophy Compass 2/2 (2007). This article provides a brief overview of the topics discussed under weeks 3–5 in the sample syllabus below. It is intended to provide a roadmap for the particular set of readings listed there. David Wiggins, 'A Sensible Subjectivism?', Needs, Values, and Truth , 3rd ed. (Oxford: Clarendon Press, 1998), 185–214. This is a stimulating paper in moral philosophy that treats Hume's essay on taste as a model for a serious subjectivism. Wiggins then presents his own brand of subjectivism as an alternative to Hume's. Online Materials: Hume's Aesthetics (Ted Gracyk): http://plato.stanford.edu/entries/hume-aesthetics/ Sample Syllabus: Recommended background reading on Hume's historical context: Peter Kivy, The Seventh Sense: Francis Hutcheson and Eighteenth-Century British Aesthetics , 2nd ed. (Oxford: Oxford University Press, 2003), especially Part III. Recommended background reading on the general topic of taste: David A. Whewell, 'Taste', Blackwell Companion to Aesthetics (Oxford: Blackwell, 1992), 415–18. Dabney Townsend and Carolyn Korsmeyer, 'Taste', Encyclopedia of Aesthetics , ed. Michael Kelly (New York, NY and Oxford: Oxford University Press, 1998), 4:355–62. Ted Cohen, 'The Philosophy of Taste: Thoughts on the Idea', Blackwell Guide to Aesthetics , ed. Peter Kivy (Oxford: Blackwell, 2004), 167–73. Week 1: Hume on beauty, art, and aesthetic judgment in the Treatise of Human Nature and the Enquiry Concerning the Principles of Morals The following references are usable for any complete edition of the Treatise or Enquiry Treatise , 2.1.8 ('Of Beauty and Deformity') Treatise , 2.2.5 ('Of Our Esteem for the Rich and Powerful') Treatise , 2.2.8 ('Of Malice and Envy'), final three paragraphs Treatise , 2.2.11 ('Of the Amorous Passion, or Love Betwixt the Sexes') Treatise , 3.1.2 ('Moral Distinctions Deriv'd from a Moral Sense') Treatise , 3.3.1 ('Of the Origin of the Natural Virtues') Treatise , 3.3.5 ('Some Farther Reflexions Concerning the Natural Virtues') Enquiry , Appendix 1 ('Of moral sentiment') Week 2: Hume's essays Essays Moral, Political, and Literary , ed. Eugene Miller (Indianapolis, IN: LibertyClassics, 1985) is the most commonly used edition today. 'Of the Delicacy of Taste and Passion' 'Of Eloquence' 'Of the Rise and Progress of the Arts and Sciences' 'Of Simplicity and Refinement in Writing' 'Of Tragedy' 'Of the Standard of Taste' Week 3: Circularity–Virtuous or Vicious? Peter Kivy, 'Hume's Standard of Taste: Breaking the Circle', British Journal of Aesthetics (1967): 57–66. David Wiggins, 'A Sensible Subjectivism?', Needs, Values, and Truth , 3rd ed. (Oxford: Clarendon Press, 1998), 185–214. Week 4: Rules of Art Mary Mothersill, 'Hume: "Of the Standard of Taste" ', Beauty Restored (Oxford: Clarendon, 1984), 177–208. James Shelley, 'Hume's Double Standard of Taste', Journal of Aesthetics and Art Criticism (1994): 437–45. Nick Zangwill, 'Hume, Taste, and Teleology', The Metaphysics of Beauty (Ithaca, NY: Cornell University Press, 2001), 149–65. Week 5: The True Judge Malcolm Budd, 'Hume and Kant', 'Hume's Standard of Taste', 'Hume and Human Nature', Values of Art (London: Allen Lane, 1995), 16–24 . Paul Guyer, 'The Standard of Taste and the "Most Ardent Desire of Society" ', Values of Beauty (Cambridge: Cambridge University Press, 2005), 37–76. Jerrold Levinson, 'Hume's Standard of Taste: The Real Problem', Journal of Aesthetics and Art Criticism (2002): 227–38. Week 6: Moralism in Aesthetic Judgment: Hume and Beyond Kendall Walton, 'Morals in Fiction and Fictional Morality', Proceedings of the Aristotelian Society (1994): 27–50. Richard Moran, 'The Expression of Feeling in Imagination', Philosophical Review (1994): 75–106. Tamar Szabo-Gendler, 'The Puzzle of Imaginative Resistance', Journal of Philosophy (2000): 55–81. Focus Questions 1. How does Hume distinguish between matters of 'fact' and 'sentiment'? 2. What is a 'rule of art', and are there any rules? 3. Can a bad critic be 'silenced'? 4. What are the characteristics of good critics? 5. Should we expect good critics to agree on the merits of a work, and should I care about becoming a good critic myself? 6. Is it possible to distinguish variations in taste for which we should expect a standard and variations for which it is 'vain' to have such an expectation? 7. How is the excellence of a work related to the exercise of taste? 8. If a work of literature has a moral outlook that differs from our own, should we consider the work defective on literary grounds? (shrink)

Eliminative materialism (or eliminativism) is the radical claim that our ordinary, common-sense understanding of the mind is deeply wrong and that some or all of the mental states posited by common-sense do not actually exist. Descartes famously challenged much of what we take for granted, but he insisted that, for the most part, we can be confident about the content of our own minds. Eliminative materialists go further than Descartes on this point, since they challenge of the existence of various (...) mental states that Descartes took for granted. (shrink)

Part I: The Life of Cognitive Science:. William Bechtel, Adele Abrahamsen, and George Graham. Part II: Areas of Study in Cognitive Science:. 1. Analogy: Dedre Gentner. 2. Animal Cognition: Herbert L. Roitblat. 3. Attention: A.H.C. Van Der Heijden. 4. Brain Mapping: Jennifer Mundale. 5. Cognitive Anthropology: Charles W. Nuckolls. 6. Cognitive and Linguistic Development: Adele Abrahamsen. 7. Conceptual Change: Nancy J. Nersessian. 8. Conceptual Organization: Douglas Medin and Sandra R. Waxman. 9. Consciousness: Owen Flanagan. 10. Decision Making: J. Frank (...) Yates and Paul A. Estin. 11. Emotions: Paul E. Griffiths. 12. Imagery and Spatial Representation: Rita E. Anderson. 13. Language Evolution and Neuromechanisms: Terrence W. Deacon. 14. Language Processing: Kathryn Bock and Susan M. Garnsey. 15. Linguistics Theory: D. Terence Langendoen. 16. Machine Learning: Paul Thagard. 17. Memory: Henry L. Roediger III and Lyn M. Goff. 18. Perception: Cees Van Leeuwen. 19. Perception: Color: Austen Clark. 20. Problem Solving: Kevin Dunbar. 21. Reasoning: Lance J. Rips. 22. Social Cognition: Alan J. Lambert and Alison L. Chasteen. 23. Unconscious Intelligence: Rhianon Allen and Arthur S. Reber. 24. Understanding Texts: Art Graesser and Pam Tipping. 25. Word Meaning: Barbara C. Malt. Part III: Methodologies of Cognitive Science:. 26. Artificial Intelligence: Ron Sun. 27. Behavioral Experimentation: Alexander Pollatsek and Keith Rayner. 28. Cognitive Ethology: Marc Bekoff. 29. Deficits and Pathologies: Christopher D. Frith. 30. Ethnomethodology: Barry Saferstein. 31. Functional Analysis: Brian Macwhinney. 32. Neuroimaging: Randy L. Buckner and Steven E. Petersen. 33. Protocal Analysis: K. Anders Ericsson. 34. Single Neuron Electrophysiology: B. E. Stein, M.T. Wallace, and T.R. Stanford. 35. Structural Analysis: Robert Frank. Part IV: Stances in Cognitive Science:. 36. Case-based Reasoning: David B. Leake. 37. Cognitive Linguistics: Michael Tomasello. 38. Connectionism, Artificial Life, and Dynamical Systems: Jeffrey L. Elman. 39. Embodied, Situated, and Distributed Cognition: Andy Clark. 40. Mediated Action: James V. Wertsch. 41. Neurobiological Modeling: P. Read Montague and Peter Dayan. 42. Production Systems: Christian D. Schunn and David Klahr. Part V: Controversies in Cognitive Science:. 43. The Binding Problem: Valerie Gray Hardcastle. 44. Heuristics and Satisficing: Robert C. Richardson. 45. Innate Knowledge: Barbara Landau. 46. Innateness and Emergentism: Elizabeth Bates, Jeffrey L. Elman, Mark H. Johnson, Annette Karmiloff-Smith, Domenico Parisi, and Kim Plunkett. 47. Intentionality: Gilbert Harman. 48. Levels of Explanation and Cognition Architectures: Robert N. McCauley. 49. Modularity: Irene Appelbaum. 50. Representation and Computation: Robert S. Stufflebeam. 51. Representations: Dorrit Billman. 52. Rules: Terence Horgan and John Tienson. 53. Stage Theories Refuted: Donald G. Mackay. Part VI: Cognitive Science in the Real World:. 54. Education: John T. Bruer. 55. Ethics: Mark L. Johnson. 56. Everyday Life Environments: Alex Kirlik. 57. Institutions and Economics: Douglass C. North. 58. Legal Reasoning: Edwina L. Rissland. 59. Mental Retardation: Norman W. Bray, Kevin D. Reilly, Lisa F. Huffman, Lisa A. Grupe, Mark F. Villa, Kathryn L. Fletcher, and Vivek Anumolu. 60. Science: William F. Brewer and Punyashloke Mishra. Selective Biographies of Major Contributors to Cognitive Science: William Bechtel and Tadeusz Zawidzki. (shrink)

The growing general interest in understanding how neuroscience can contribute to explanations of our understanding and appreciation of art has been slow to find its way to philosophy of literature. Of course this is not to say that neuroscience has not had any influence on current theories about our engagement, understanding, and appreciation of literary works. Colin Martindale developed a scientific approach to literature in his book The Clockwork Muse (1990). His prototype-preference theory drew heavily on early artificial neural network (...) research. Jenefer Robinson has appealed to results from affective neuroscience in her discussion of our emotional engagement with literary works (see Robinson, 2005). More recently literary critics have tried to extend cognitive literary theory in the direction of neuroscience (Ashton, 2005; Byatt, 2006; Young, 2010). This line of research traces its origin to commentary on a 1995 a paper by Herbert Simon in the Stanford Humanities Review (Franchi and Güzeldere, 1995). So, although there hasn't been much going on that could justifiably be called a neuroscience of literature, discussions of neuroscientific research have woven their way into the fabric of some aspects of philosophy of literature and literary theory. Nonetheless, there has been a great deal of resistance to the creeping insurgence of neuroscience into both fields. I will challenge this skepticism in what follows. In section 1, I will sketch a model for research at the crossroads of philosophy and neuroscience of art and suggest how it can be applied to the philosophy of literature. In Section 2, I will introduce situation models and discuss the role they have been hypothesized play in discourse comprehension and narrative understanding outside of literature. In Section 3, I will explore some ways that situation models can contribute to discussions of narrative understanding, appreciation, and the artistically salient features that differentiate literature as a category of art from non-art literary forms like newspaper columns, magazine articles, or biographies. (shrink)

In early 1984, the AIDS epidemic was less than four years old. Chemists at the pharmaceutical company Syntex, situated in the rolling green hills near Stanford University in Palo Alto, California, had recently synthesized a new antiviral drug (Martin et al. 1983). The drug, at first given the awkward chemical abbreviation DHPG, later came to be known by the generic name ganciclovir. Ganciclovir was a potent drug for the treatment of herpes virus infection (such as genital herpes or chickenpox), (...) but the unique characteristic of ganciclovir was that it worked against cytomegalovirus (CMV), a heretofore untreatable virus infection. Although relatively harmless in healthy individuals, CMV caused .. (shrink)

This guest column, written by a former president of Emory University, examines arguments made by Jonathan Cole, a former provost of Columbia, in his book The Great American University. Cole illustrates his history of the modern American research university with a vivid comparison between two eminent academic leaders of the last century, Jacques Barzun of Columbia and Frederick Terman of Stanford. Employing data generated by the Shanghai Jiao Tong University Institute for Higher Education and Times Higher Education, Cole shows (...) that universities are today ranked in order of prestige and eminence on the basis of their wealth and the magnitude of the support they receive for research activities. American universities, richer than all others, have greater resources to deploy and therefore are considered “the best.” Among them, Columbia and Stanford are among the very best. But, for Cole, Stanford has lately become superior to Columbia because Terman was more forward-looking, more ambitious in securing external support from government and industry, and more interested in building the strength of disciplines close to industry, commerce, and practical results. Barzun was more traditional, interested in supporting and encouraging the humanities, and “stuck in the historical past.” Cole reports that where Terman saw opportunities in the future, Barzun saw threats. Cole's book leaves many questions unanswered. In universities increasingly funded externally, what stance should academic administrators take toward professors more interested in their disciplines than in their employer? What is the fate of the underfunded humanities? What can be done about the stunning increase in tuition prices? Transfixed by Terman's definition of eminence, Cole ignores these difficult realities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:On Dante, Hyperspheres, and the Curvature of the Medieval CosmosWilliam EggintonIn the course of his lectures on medieval literature at Oxford University in the 1950s C. S. Lewis would ask students to walk alone at night, gaze at the star-filled sky, and try to imagine how it might look to a walker in the Middle Ages. It would not likely have occurred to him that some forty years later (...) several astrophysicists would ask that their readers perform the same activity, at least figuratively—not, however, with the intention of experiencing medieval conceptions of the cosmos but rather in order to begin to imagine the shape of our own. One of the astrophysicists in question is Stanford Professor Emeritus Robert Osserman, whose 1995 book The Poetry of the Universe is an attempt to acquaint lay readers with what the most recent research suggests is the shape of the universe by leading them through a brief history of the mathematical and technological developments that made such boundary-breaking thought possible. Paradoxically, when it comes to trying to imagine that all-encompassing form which is derived from a four-dimensional mathematical model called a hypersphere, he turns not to ultra-modern computer-generated images nor to dry but technically accurate exegeses of mathematical formulae but rather to the verses of a fourteenth-century Italian poet, Dante Alighieri. His claim is that in the third canticle of the Divine Comedy, which details his ascent through the heavens, Dante describes the cosmos with astonishing precision as a hypersphere, exactly as modern physics has determined it to be.If the cosmology of the present makes use of Dante heuristically, however, it never asks the most obvious question: Why? Why does one need to go back to the fourteenth century for a poetic description of how the universe appears to modern science? Osserman assumes it to be a mere coincidence, and why should he not? What possible access would a thinker—a poet even—of the European Middle Ages have to the highest achievements of almost six centuries of subsequent thought? In answering this question, I am not proposing to naively interpret the past in our own image, claiming Dante to be a mathematical genius [End Page 195] before his time. I am, however, suggesting that there is an excellent explanation for why one must look to the fourteenth century for models of expression adequate to the challenges posed by nineteenth and twentieth-century advances in mathematics: namely, that in the course of the Scientific Revolution, wherein were laid the epistemological foundations for the discoveries of modern science, certain possibilities of thought and imagination were discarded, forgotten, and certain abilities were, if only temporarily, lost. The Middle Ages has long been painted as a period whose culture was hostile to free thought and new knowledge; perhaps it is now time to recognize that it was also a time in which phenomena could sustain mutually exclusive and contradictory explanations, when the battle between faith and science had not yet been conclusively won by either side, and when the efforts to bridge the stories they told could produce conceptual edifices whose mere possibility would be unthinkable only 200 years later. This essay is about one such conceptual edifice and how openness to its perspective allowed a poet to put into words what could not be imagined by his descendants, and what eludes us even today.The Shape of the Modern UniverseImagine that you are a completely flat creature, living happily in your two-dimensional world.1 As observers we are outside this world, and we can see you milling about with your flat friends, blissfully unaware of the uncharted regions one dimension away on either side of you. Now imagine that this plane is not flat—in the sense of rectilineal—as you might have created it in your mind, but rather is curved; in fact it is a sphere. Assuming that this sphere is large enough, there is no reason that you, an inhabitant of this surface, should be aware of its curvature. Even we, the three-dimensional observers, if close enough to the surface, would not recognize its curvature. One could conjecture, however... (shrink)

The personal papers of the neurophysiologist John C. Lilly at Stanford University hold a classified paper he wrote in the late 1950s on the behavioural modification and control of ‘human agents’. The paper provides an unnerving prognosis of the future application of Lilly’s research, then being carried out at the National Institute of Mental Health. Lilly claimed that the use of sensory isolation, electrostimulation of the brain, and the recording and mapping of brain activity could be used to gain (...) ‘push-button’ control over motivation and behaviour. This research, wrote Lilly, could eventually lead to ‘master-slave controls directly of one brain over another’. The paper is an explicit example of Lilly’s preparedness to align his research towards Cold War military aims. It is not, however, the research for which Lilly is best known. During the 1960s and 1970s, Lilly developed cult status as a far-out guru of consciousness exploration, promoting the use of psychedelics and sensory isolation tanks. Lilly argued that, rather than being used as tools of brainwashing, these techniques could be employed by the individual to regain control of their own mind and retain a sense of agency over their thoughts and actions. This article examines the scientific, intellectual, and cultural relationship between the sciences of brainwashing and psychedelic mind alteration. Through an analysis of Lilly’s autobiographical writings, I also show how paranoid ideas about brainwashing and mind control provide an important lens for understanding the trajectory of Lilly’s research. (shrink)

Two of the most prominent questions in Kant's critical philosophy concern reason. The first, central to his theoretical philosophy, is the unprovable pretensions of reason in earlier “rationalist” philosophers, especially Leibniz and Descartes. The second, central to his practical philosophy, is the subservient role accorded to reason by the British empiricists—above all Hume, who declared, “Reason is wholly inactive, and can never be the source of so active a principle as conscience, or a sense of morals.” Treatise, 3.1.1.11; see also (...) the entry on Rationalism vs. Empiricism .) Thus the titles of two key works: the monumental Critique of Pure Reason, and the Critique of Practical Reason that is middle point of his great trio of moral writings (between the Groundwork of the Metaphysics of Morals and The Metaphysics of Morals). (shrink)